131However, many of the studies that showed increased tumordevelopment used animals that had been genetically engineeredor treated with cancer-causing chemicals so as to be pre-disposed to develop cancer in absence of RF exposure. Otherstudies exposed the animals to RF for up to 22 hours per day.These conditions are not similar to the conditions under whichpeople use wireless devices, so we don't know with certaintywhat the results of such studies mean for human health.Three large epidemiology studies have been published sinceDecember 2000. Between them, the studies investigated anypossible association between the use of wireless devices andprimary brain cancer, glioma, meningioma, or acoustic neuroma,tumors of the brain or salivary gland, leukemia, or other cancers.None of the studies demonstrated the existence of any harmfulhealth effects from wireless devices RF exposures. However,none of the studies can answer questions about long-termexposures, since the average period of device use in thesestudies was around three years.What research is needed to decide whether RFexposure from wireless devices poses a health risk?A combination of laboratory studies and epidemiological studiesof people actually using wireless devices would provide some ofthe data that are needed. Lifetime animal exposure studies couldbe completed in a few years. However, very large numbers ofanimals would be needed to provide reliable proof of a cancerpromoting effect if one exists. Epidemiological studies canprovide data that is directly applicable to human populations, butten or more years' follow-up may be needed to provide answersabout some health effects, such as cancer. This is because theinterval between the time of exposure to a cancer-causing agentand the time tumors develop - if they do - may be many, manyyears. The interpretation of epidemiological studies is hamperedby difficulties in measuring actual RF exposure during day-to-dayuse of wireless devices.Many factors affect this measurement, such as the angle atwhich the device is held, or which model of device is used.What is FDA doing to find out more about the possiblehealth effects of wireless device RF?FDA is working with the U.S. National Toxicology Program andwith groups of investigators around the world to ensure that highpriority animal studies are conducted to address importantquestions about the effects of exposure to radio frequencyenergy (RF). FDA has been a leading participant in the WorldHealth Organization international Electromagnetic Fields (EMF)Project since its inception in 1996. An influential result of thiswork has been the development of a detailed agenda of researchneeds that has driven the establishment of new researchSWD-M100.book Page 131 Monday, March 8, 2010 8:09 AM